Comedian Marc Maron has an interesting podcast called "WTF," in which he sits down for one-on-one in-depth conversations with other comedians. They talk about their latest projects, the process behind their craft, stories from the road, experiences they've shared, etc. I've downloaded and enjoyed several of the shows he's done them out of his garage with friends like Louis CK, Sarah Silverman, Adam McKay, and Bob Saget.
I just got around to one from last October that quickly became my favorite -- a discussion with Ray Romano and Mike Royce about their TNT series "Men Of A Certain Age," which has been must-see TV in our house since episode one. You can get Maron's podcasts via iTunes, or listen to that particular show here.